ACUTE TOXICITY TESTS Meaning and
Definition
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Acute Toxicity Tests refer to laboratory experiments conducted to determine the immediate harmful effects of a substance or chemical on living organisms. This type of testing is performed to assess the potential dangers that a substance may pose after a single exposure, often through ingestion, inhalation, or direct contact with the skin or eyes. The tests are usually carried out on animals, such as rodents or rabbits, as they are representative of biological systems and can provide insight into potential impacts on humans.
The experiments involve exposing the test subjects to varying concentrations or doses of the substance being tested and monitoring their response. The observations typically include changes in behavior, physiological functions, and any adverse effects exhibited by the animals. The outcomes of acute toxicity tests help determine the median lethal dose (LD50), which is the dose at which 50% of the test subjects are expected to die.
These tests serve as an essential part of safety evaluations for various industries, including pharmaceuticals, pesticides, cosmetics, and other chemical manufacturing sectors. The results obtained from acute toxicity tests aid in determining appropriate safety precautions, regulations, and potential health hazards associated with the tested substances. However, it is important to note that there are ongoing efforts to minimize or replace animal testing with alternative testing methods, such as in vitro assays or computer models, to ensure more ethical and reliable assessments of acute toxicity.
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