ASKANAZY CELL Meaning and
Definition
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An Askanazy cell, also known as an Askanazy-Azurgranulom cell, is a specialized type of cell found within the human body, primarily in the bone marrow. It is a large, multinucleated cell that is typically associated with certain pathological conditions, particularly chronic inflammation and infectious diseases. The cell was named after the German anatomist Ludwig Askanazy, who first identified and described it.
Askanazy cells are characterized by their distinctive appearance, with numerous nuclei and a granular cytoplasm that stains with azurophilic granules. These granules contain enzymes and other substances that are involved in the cell's defense mechanisms, particularly phagocytosis and the destruction of foreign particles or microorganisms.
These cells are predominantly seen in several medical conditions, such as tuberculosis, sarcoidosis, and certain fungal infections. Their presence indicates the presence of chronic inflammation within the affected tissues. Askanazy cells infiltrate the area of inflammation and are believed to be involved in the body's immune response to combat the underlying infection or disease.
In pathology, the identification of Askanazy cells in a tissue sample can be useful in diagnosing and distinguishing specific diseases based on their characteristic appearance. However, it is important to note that the presence of these cells alone is not sufficient for a definitive diagnosis, as further clinical and laboratory investigations are typically required for accurate disease identification and management.
Common Misspellings for ASKANAZY CELL
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Etymology of ASKANAZY CELL
The term "Askanazy cell" is derived from the name of a German pathologist named Leopold Askanazy.
Leopold Askanazy (1866-1940) was a renowned German physician and pathologist who specialized in the study of blood cells and blood disorders. He made significant contributions to the field, particularly in the understanding of cellular pathology in various diseases.
The specific term "Askanazy cell" refers to a type of abnormal cell found in the bone marrow, specifically in cases of myeloproliferative neoplasms. These cells are characterized by their large size, abnormal shape, and increased nuclear-cytoplasmic ratio.
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