CIS ACTING Meaning and
Definition
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Cis acting refers to a term used in genetics and molecular biology to describe a sequence or element of DNA that affects the expression or regulation of genes on the same DNA molecule. The term "cis" is derived from Latin, meaning "on the same side," and is used to specify that the element is present on the same molecule of DNA, rather than on a separate molecule or chromosome.
In gene expression, cis acting elements can be various DNA sequences, such as promoters, enhancers, or silencers, that regulate the transcription and translation of genes. These elements typically occur upstream or downstream of the gene they regulate. Cis acting elements interact with transcription factors and other regulatory proteins to either enhance or suppress the expression of a nearby gene.
Cis acting elements are essential for proper gene regulation, as they control the timing, location, and level of gene expression. Mutations or alterations in cis acting elements can lead to dysregulation of gene expression, which may have consequences ranging from benign to pathogenic.
Cis acting elements are distinct from trans acting elements, which are gene regulatory elements present on different DNA molecules. Trans acting elements can act in a manner independent of their location, whereas cis acting elements function specifically on the DNA molecule where they are situated.
Understanding cis acting elements and their interactions within the genome is crucial for comprehending the intricate mechanisms underlying gene regulation and expression. Research into cis acting elements has provided valuable insights into numerous biological processes, including development, cell differentiation, and disease.
Common Misspellings for CIS ACTING
- xis acting
- vis acting
- fis acting
- dis acting
- cus acting
- cjs acting
- cks acting
- cos acting
- c9s acting
- c8s acting
- cia acting
- ciz acting
- cix acting
- cid acting
- cie acting
- ciw acting
- cis zcting
- cis scting
- cis wcting
- cis qcting
Etymology of CIS ACTING
The term "cis acting" comes from the Latin word "cis", which means "on this side" or "on the same side". In molecular biology, "cis acting" describes regulatory elements or sequences that are located on the same side of a DNA molecule as the gene they regulate. These cis-acting elements control the expression of genes by binding to specific transcription factors or other regulatory molecules. The term was first used in the field of molecular genetics in the 1970s, and it contrasts with "trans acting", which refers to regulatory factors that can bind to and act upon DNA sequences located on different DNA molecules or chromosomes.
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