Fibrin tissue adhesive is a biological substance that is used in medical procedures to promote the healing and sealing of injured tissue. It is composed of fibrinogen and thrombin, two proteins that are naturally present in the blood clotting process. When used in clinical settings, fibrin tissue adhesive is typically applied topically to the site of a surgical incision or wound.
The adhesive acts by mimicking the final steps of the blood clotting cascade. Fibrinogen, which circulates in the blood as a soluble protein, is converted into fibrin through the action of thrombin. Fibrin forms a mesh-like structure that helps to stabilize the wound and bind tissue together, enabling the body's natural healing processes to take place more efficiently.
Fibrin tissue adhesive offers several advantages over traditional wound closure techniques, such as sutures or staples. It provides immediate hemostasis, preventing excessive bleeding, and creates a seal that helps to minimize the risk of infection. Furthermore, it does not require removal, as it is gradually broken down and absorbed by the body.
This adhesive is commonly utilized in various surgical procedures, including cardiovascular, neurosurgery, orthopedic, and general surgery. It has also found applications in dentistry and ophthalmology. Fibrin tissue adhesive is generally well-tolerated, with rare allergic reactions reported.
In summary, fibrin tissue adhesive is a biological substance that promotes wound healing and tissue sealing. It is composed of fibrinogen and thrombin, and it mimics the natural blood clotting process. This adhesive has numerous applications in surgical procedures and offers advantages such as hemostasis, infection prevention, and ease of use.
