Mouse Hepatitis Viruses (MHV) are a group of viruses that primarily infect mice. These viruses belong to the Coronaviridae family and have a single-stranded RNA genome. MHV is known to cause a highly contagious and potentially fatal disease in mice called mouse hepatitis.
MHV is characterized by its ability to infect multiple organs, including the liver, lungs, intestines, and central nervous system. It primarily spreads through respiratory secretions, feces, or contaminated surfaces. The virus can be transmitted through direct contact with infected mice, aerosol droplets, or fomites.
The symptoms of mouse hepatitis in infected mice vary depending on the viral strain and the age and genetic susceptibility of the host. Common manifestations include mild respiratory distress, weight loss, diarrhea, central nervous system disorders, and ultimately, liver and kidney failure. Neonatal mice are particularly vulnerable to MHV, as the infection can lead to severe morbidity and mortality.
Mouse hepatitis viruses are significant not only for their impact on laboratory mice, but also for their potential implications in scientific research. MHV strains are frequently used as models to study various aspects of human coronavirus infections, particularly the development of vaccines, antiviral therapies, and the understanding of viral pathogenesis.
In summary, Mouse Hepatitis Viruses are a group of highly contagious coronaviruses that primarily infect mice, causing a range of clinical symptoms. Understanding these viruses and their transmission is essential not only in protecting laboratory rodents but also in advancing our knowledge of human coronaviruses.
