Multiple Symmetrical Lipomatoses, also known as Madelung's disease or benign symmetric lipomatosis, is a rare condition characterized by the abnormal growth of fatty tissue deposits in multiple areas of the body. This disorder predominantly affects middle-aged men, although it can occur in women as well. The word "multiple" indicates that the growths usually appear in various locations on the body, whereas "symmetrical" means that the growths are consistently present on both sides of the body.
Individuals with Multiple Symmetrical Lipomatoses showcase the development of multiple clusters or masses of fatty tissue, called lipomas, which typically occur around the neck, upper arms, upper trunk, and shoulders. These lipomas can gradually increase in size over time, leading to disfigurement and functional impairments in severe cases. The condition often shows a tendency towards progression, with new lipomas forming even after the removal of existing ones.
The exact cause of Multiple Symmetrical Lipomatoses remains unknown, although it is believed to be linked to a genetic mutation that predisposes individuals to develop this disorder. Other contributing factors, such as hormone imbalances, alcohol intake, and metabolic dysfunctions, have also been suggested.
Symptoms of Multiple Symmetrical Lipomatoses may include pain, impaired mobility, difficulty swallowing or speaking, as well as potential respiratory problems if the lipomas accumulate near the neck. Treatment options for this condition generally involve lipoma removal through surgical excision, liposuction, or, in some cases, ongoing surveillance. Additionally, managing concurrent medical conditions and adopting a healthy lifestyle, including proper nutrition, regular exercise, and abstaining from alcohol, may be recommended to mitigate the progression of the disorder.
