MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME Meaning and
Definition
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Murine Acquired Immunodeficiency Syndrome (MAIDS) is a medical condition primarily observed in laboratory mice that compromises their immune system and leaves them susceptible to opportunistic infections. It is caused by a retrovirus known as the LP-BM5 virus strain, which is a combination of various murine leukemia viruses. The LP-BM5 virus targets and infects cells of the immune system, leading to progressive immune dysfunction.
The hallmark of MAIDS is the gradual depletion of CD4+ T cells, a crucial component of the immune system responsible for coordinating the body's response to infections. This selective destruction of CD4+ T cells results in weakened immune responses, diminished ability to fight off infections, and increased susceptibility to a variety of pathogens.
Affected mice with MAIDS may exhibit symptoms such as weight loss, lethargy, anemia, increased susceptibility to tumors, and an increased rate of mortality. Additionally, these mice are prone to developing various opportunistic infections, including bacterial, viral, and fungal infections. MAIDS has been closely studied due to its similarities to human acquired immunodeficiency syndrome (AIDS), and the insights gained from researching MAIDS have contributed to our understanding of HIV/AIDS in humans.
In conclusion, Murine Acquired Immunodeficiency Syndrome refers to a retroviral-induced condition in mice that leads to the depletion of CD4+ T cells, compromising their immune system and leaving them vulnerable to opportunistic infections.
Common Misspellings for MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME
- nurine acquired immunodeficiency syndrome
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