How Do You Spell OTSUKA LONG EVANS TOKUSHIMA FATTY RATS?

1. Otsuka Long Evans Tokushima Fatty Rats (OLETF rats) are a specific strain of laboratory rats that have been selectively bred and developed for research purposes. These rats are widely used in scientific studies related to obesity, diabetes, and metabolic syndrome, as they exhibit characteristics and features that make them ideal for these types of investigations.

   The OLETF rats are named after the institutions involved in their development. Otsuka Pharmaceutical Co., Ltd., located in Japan, contributed to the strain's establishment. Long Evans is a reference to the rat strain from which the original breeders started the breeding program, while Tokushima signifies the region in Japan where the particular breeding colony was maintained. Fatty Rats, as the name implies, refers to the strain's natural predisposition to developing obesity due to a genetic mutation.

   The primary characteristic of OLETF rats is their propensity to develop a range of metabolic disorders when fed a standard laboratory diet. These disorders include obesity, hyperlipidemia (abnormally high levels of lipids in the blood), insulin resistance, and Type 2 diabetes-like symptoms. The development of these conditions is influenced by a mutation in the leptin receptor gene, which plays a crucial role in regulating appetite and energy balance.

   Researchers utilize OLETF rats to study the underlying mechanisms of obesity-related diseases, test the efficacy of potential therapeutic interventions, and explore the impact of various genetic and environmental factors on metabolic disorders. These rats serve as valuable models for understanding human diseases and contribute to the advancement of biomedical research.

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