How Do You Spell PEPTIDYL PROLYL CIS TRANS ISOMERASE?

1. Peptidyl prolyl cis trans isomerase (PPI) is an enzyme that catalyzes the rearrangement of the peptide bond between two adjacent amino acids, specifically proline residues, from one conformation (cis) to another (trans). This enzyme plays a crucial role in protein folding and function by facilitating the interconversion between the cis and trans conformations of peptidyl prolyl bonds.

   The cis and trans conformations refer to the spatial arrangement of the peptide bond, particularly around the proline residue. In the cis conformation, the amino and carboxyl groups of the peptide bond are located on the same side of the proline ring, while in the trans conformation, they are located on opposite sides. This conformational change can significantly affect the overall structure and stability of a protein.

   The peptidyl prolyl cis trans isomerase enzyme acts as a catalyst in this process, increasing the rate of cis-trans isomerization by several orders of magnitude. It achieves this by binding to the proline residue and exerting a torsional strain, which promotes the rotation of the peptide bond into the trans conformation.

   Given its essential role in protein folding, peptidyl prolyl cis trans isomerase is involved in numerous cellular processes, including protein degradation, signal transduction, and immune response. It is also considered a potential target for therapeutic interventions, as its dysregulation has been linked to various diseases, such as neurodegenerative disorders and cancer.

Common Misspellings for PEPTIDYL PROLYL CIS TRANS ISOMERASE

Plural form of PEPTIDYL PROLYL CIS TRANS ISOMERASE is PEPTIDYL PROLYL CIS TRANS ISOMERASES

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