PLKINASE is a term that refers to polo-like kinase, a type of enzyme involved in cell cycle regulation and various cellular processes. It is a protein kinase that plays a crucial role in cell division, particularly during mitosis, as well as in other aspects of cell proliferation and DNA damage response.
Polo-like kinases are named after the polo gene in Drosophila melanogaster, mutants of which display defects in spindle formation during mitosis. PLKINASE is a member of the polo-like kinase family and plays a key role in coordinating and regulating various events during cell division.
The primary function of PLKINASE is to ensure proper cell cycle progression by phosphorylating specific substrates involved in mitotic processes. It controls mitotic entry, centrosome maturation, bipolar spindle formation, chromosome alignment, and cytokinesis, among other important events. Additionally, PLKINASE is also involved in DNA repair, cell survival, and apoptosis.
Aberrant expression or dysregulation of PLKINASE has been associated with several human diseases, including cancer. Its overexpression has been observed in various tumor types and is associated with poor prognosis. Due to its critical role in cell division and its implication in disease, PLKINASE has attracted considerable attention as a potential target for cancer treatment.
In summary, PLKINASE is a polo-like kinase enzyme that regulates cell cycle progression and other cellular processes. Its main function is to ensure proper mitotic events and it has been implicated in various diseases, particularly cancer.
