SMALL GTPASE ACTIVATORS Meaning and
Definition
-
Small GTPase activators are a class of molecules that play a vital role in regulating the activity of small GTPases. Small GTPases are a family of enzymes that act as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state. They are involved in various cellular processes, including cell division, cell migration, and intracellular signaling.
Small GTPase activators, as the name suggests, are molecules that catalyze the activation of small GTPases by promoting the exchange of GDP (guanosine diphosphate) with GTP (guanosine triphosphate) on the GTPase. This exchange, known as nucleotide exchange, is a crucial step in switching the GTPase from an inactive to an active form.
The activators achieve this activation by binding to the inactive GDP-bound small GTPases and facilitating GDP release. They subsequently promote the binding of GTP to the GTPase, leading to a conformational change and activation of downstream signaling pathways. Small GTPase activators can act as guanine nucleotide exchange factors (GEFs) or as indirect activators that modulate the activity of GEFs.
Small GTPase activators are essential for maintaining proper cellular functions and contribute to various physiological and pathological processes. Dysregulation of these activators has been associated with numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, understanding the mechanisms of small GTPase activation and the role of activators is crucial for developing potential therapeutic interventions that target aberrant signaling pathways.
Common Misspellings for SMALL GTPASE ACTIVATORS
- amall gtpase activators
- zmall gtpase activators
- xmall gtpase activators
- dmall gtpase activators
- emall gtpase activators
- wmall gtpase activators
- snall gtpase activators
- skall gtpase activators
- sjall gtpase activators
- smzll gtpase activators
- smsll gtpase activators
- smwll gtpase activators
- smqll gtpase activators
- smakl gtpase activators
- smapl gtpase activators
- smaol gtpase activators
- smalk gtpase activators
- smalp gtpase activators
- smalo gtpase activators
- small ftpase activators
Infographic
Add the infographic to your website:
