DNA GYRASE A SUBUNIT Meaning and
Definition
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DNA gyrase A subunit is an essential component of the DNA gyrase enzyme, an enzyme present in bacteria that plays a crucial role in DNA replication and repair processes. It is a type II topoisomerase, responsible for introducing negative supercoils into DNA molecules, thereby altering their structural conformation. The DNA gyrase A subunit consists of a single polypeptide chain encoded by the gyrA gene.
The DNA gyrase A subunit possesses several functional domains, including an ATPase domain and a DNA-binding domain. Its ATPase activity is vital for the energy-dependent DNA supercoiling activity of the enzyme. The ATPase domain is responsible for hydrolyzing ATP molecules, providing the required energy to catalyze the DNA gyrase reaction. The DNA-binding domain allows the subunit to specifically recognize and bind to DNA molecules.
The DNA gyrase A subunit has been extensively studied due to its significance as a target for certain antibiotics. Some antibiotics, such as fluoroquinolones, inhibit the activity of DNA gyrase by selectively binding to this subunit, thereby impeding the enzyme's ability to introduce negative supercoils into DNA. By interfering with DNA gyrase, these antibiotics inhibit DNA replication, leading to bacterial cell death.
Overall, the DNA gyrase A subunit serves as a key component of the DNA gyrase enzyme, contributing to the accurate replication and efficient repair of DNA molecules in bacteria. Its structural and functional attributes make it a prime target for antibiotics, making it an important subject of research in the field of antimicrobial drug development.
Common Misspellings for DNA GYRASE A SUBUNIT
- sna gyrase a subunit
- xna gyrase a subunit
- cna gyrase a subunit
- fna gyrase a subunit
- rna gyrase a subunit
- ena gyrase a subunit
- dba gyrase a subunit
- dma gyrase a subunit
- dja gyrase a subunit
- dha gyrase a subunit
- dnz gyrase a subunit
- dns gyrase a subunit
- dnw gyrase a subunit
- dnq gyrase a subunit
- dna fyrase a subunit
- dna vyrase a subunit
- dna byrase a subunit
- dna hyrase a subunit
- dna yyrase a subunit
- dna tyrase a subunit
Similar spelling word for DNA GYRASE A SUBUNIT
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